以色列Ben Gurion University博士后招聘

　　研究内容:

　　 1.I am looking for a postdoctoral fellow to work on the cold inactivation of enzymes. The research entails: structure determination by X ray crystallography, molecular biology, biophysics and biochemistry. Work is related to the quaternary structure of proteins, protein-protein interaction, and the role of hydrophobic interactions in maintaining the quaternary structure of proteins. It includes enzyme kinetics, HPLC studies of dissociation of oligomric proteins, calorimetry and high pressure studies. This project is in collaboration with Dr. Orna Almog from the Clinical Biochemistry Department here, and Prof. Phillips from Georgia Univ, USA.

     2. What is it that controls bacterial cell division in space and in time? This is still an enigmatic matter to biologists. We have a working hypothesis which we try to advance as a possible mechanism for bacterial cell cycle. We look for a postdoc to approach this problem by studying model giant liposomes and black membrane interaction with DnaA protein, the protein which initiated the bacterial genome replication. Techniques to be used in the research are: single molecule fluorescence—by fluorescence correlation spectroscopy with confocal microscopy, FRET, homo-FRET and red edge fluorescence. A strong physical chemistry background is preferred. Work is to be conducted under the collaborative supervision of Prof. Y. Fishov from the Department of life Sciences Prof. Oleg Kriechevsky from the Physics Department and Prof.A.H. Parola form the Chemistry Department.

    合作导师:

     Abraham H. Parola, Professor and Dean of the Faculty of Natural Sciences.

    代表性论文:

    1. Avraham, H., Ohana, E., Maymon, E., Cohen-Luria, R., Molcho, J., and Parola, A.H., Intrinsic fluorescence polarization of amniotic fluid: II. Toward a noninvasive method for the determination of fetal lung maturity. Photochemistry and Photobiology, 2006. 82(6): p. 1591-1594.

    2.Aranovich, A., Gdalevsky, G.Y., Cohen-, R., Fishov, I. and Parola, A.H., Membrane-catalyzed nucleotide exchange on DnaA - Effect of surface molecular crowding. Journal of Biological Chemistry, 2006. 281(18): p. 12526-12534.

    3.Kogan, A., Gdalevsky, G.Y., Cohen-Luria, R., Parola, A.H. and Goldgur, Y., Crystallization and preliminary X-ray analysis of the apo form of Escherichia coli tryptophanase. Acta Crystallographica Section D-Biological Crystallography, 2004. 60: p. 2073-2075.

    4.Molcho, J., Avraham, H., Cohen-Luria, R. and Parola, A.H., Intrinsic fluorescence polarization of amniotic fluid: Evaluation of human fetal lung maturity. Photochemistry and Photobiology, 2003. 78(2): p. 105-108.

    5.Vanounou, S., Pines, D., Pines, E., Parola, A.H. and Fishov, I., Coexistence of domains with distinct order and polarity in fluid bacterial membranes. Photochemistry and Photobiology, 2002. 76(1): p. 1-11.

    欢迎垂询:

     一般性问题请联系dafeng129@yahoo.com.cn

     导师信箱:  aparola@bgu.ac.il

     Phone:  +972-8-647-2454, 972-52-8795945

     Fax:  +972-8-647-2943

     导师主页:http://www.bgu.ac.il/chem/eng/personal/parola.html